Chris Brunt and Wade Small will both miss the game against Cardiff on Saturday after the appeal against their dismissals failed.
Small was sent off in the 16th minute for violent conduct and has received a three match ban. Brunt, who actually put the Owls ahead, was red carded before half time for a professional foul and gets a one match ban.
Coventry came from a goal down to beat the 9 men by 3 goals to 1.