MK Dons boss Karl Robinson, who made 10 changes for the first-round win over Leyton Orient, is likely to give a debut to on-loan winger Josh Murphy.
He could also recall goalkeeper Cody Cropper and defenders Lee Hodson and Matthew Upson to the starting line-up.
Cardiff striker Kenwyne Jones is doubtful because of an ankle injury, but Bruno Manga and Federico Macheda look set to be involved.
Midfielder Scott Malone could return from a virus.
MATCH FACTS
MK Dons have won four of their last five second-round games, losing the other away at Sunderland in 2013.
Cardiff have won three of their last four away League Cup games.
This is the third meeting in 11 years between the two sides in the League Cup second round, Cardiff winning the previous two in 2004 and 2008.
The Bluebirds have won eight of their previous nine second round ties.