It's the first international to be held at City's new ground and is sure not to be the last.
Tickets are on sale for Welsh fans from the Cardiff City ticket office 0845 345 1400 and are £20 for adults with various concession rates and family ticket options.
Scotland squad
Goalkeepers: Craig Gordon (Sunderland), Jamie Langfield (Aberdeen), David Marshall (Cardiff)
Defenders: Christophe Berra (Wolves), Gary Caldwell (Celtic), Steven Caldwell (Burnley), Danny Fox (Celtic), Alan Hutton (Tottenham), Stephen McManus (Celtic), Lee Wallace (Hearts), Steven Whittaker (Rangers)
Midfielders: Don Cowie (Watford), Graham Dorrans (West Brom), Darren Fletcher (Manchester United), Ross McCormack (Cardiff), James McFadden (Birmingham), Barry Robson (Celtic), Kevin Thomson (Rangers)
Forwards: Steven Fletcher (Burnley), Kevin Kyle (Kilmarnock), Kenny Miller (Rangers), Steven Naismith (Rangers), Derek Riordan (Hibernian).