Sol Bamba, Jonny Williams, Joe Bennett, Junior Hoilett and Joe Day will leave Cardiff City this summer, writes BBC Wales.
Defender Bamba has been battling non-Hodgkin lymphoma but announced in May he was "cancer free".
The 36-year-old plus defender Bennett, 31, and winger Hoilett, 30, joined in 2016 but are all now out of contract.
Midfielder Williams, 27, who is part of Wales' Euro 2020 squad, only joined in February, while goalkeeper Day, 30, has been on loan at Bristol Rovers.
A statement from the Championship club said: "Our departing Bluebirds will always be welcome here at Cardiff City Stadium and we wish them all the very best for the future."
Bamba made 118 appearances for the Bluebirds having arrived as a free agent in October 2016, scoring the winner on his debut against Bristol City in what was also Neil Warnock's first game in charge of the club.
The Ivory Coast international's immediate impact - and rapport with Warnock - helped move the club from relegation worries to a mid-table finish, before promotion to the Premier League the following season.
Bamba played in every game of that successful promotion campaign and was named in the Championship team of the season.
Hoilett had similar success, making his debut in the same match after his own free transfer to Cardiff City Stadium, going on to play 185 games for the south Wales club, scoring 25 goals.
Bamba had already struggled to hold down a regular place following the club's relegation in 2019 before his well-publicised health battle this year.
He did make one last appearance as a late substitute in the final-day draw with Rotherham.
Hoilett had also seen opportunities limited following the arrival of Mick McCarthy as manager and announced he was set to leave last month, while Bennett has not played since suffering cruciate knee liagement damage in a Championship match against Derby County in March.
Williams, currently part of the Wales Euro 2020 squad, was signed by McCarthy on a short-term deal but only made nine appearances.
Meanwhile, Day managed just one start in his time at Cardiff City Stadium having made the switch from near neighbours Newport County in 2019
Full list from www.cardiffcityfc.co.uk
2020/21 Retained List
First team
Leandro Bacuna
Joel Bagan
Ciaron Brown
Rubin Colwill
Aden Flint
Robert Glatzel
Mark Harris
Kieffer Moore
Sean Morrison
Josh Murphy
Curtis Nelson
Perry Ng
Marlon Pack
Dillon Phillips
Joe Ralls
Tom Sang
Alex Smithies
Lee Tomlin
Isaac Vassell
Will Vaulks
Max Watters
Gavin Whyte
Retained Under 23s
Ibrahim Bakare
Sam Bowen (contract offered)
Isaak Davies
Oliver Denham
Kieron Evans
Caleb Hughes
Tavio D'Almeida
Ntazana Mayembe
Keenan Patten
George Ratcliffe
Chanka Zimba
Departing U23s: Jack Bodenham, Aaron Bolger, Daniel Griffiths, Roland Idowu, Daniel Martin, Camron McWilliams, Ryan Reynolds, James Waite, Jack Williams, Ben Margetson.
Retained scholars
Jac Clay
Benjamin Coley
James Crole
Thomas Davies
Aidan MacNamara
Joshua Rippon
Rhys Schwank
Contracts offered: Taylor Jones, Ryan Kavanagh, Eli King, Siyabonga Ligendza, Owen Pritchard and Nativ Yanko.
Departing scholars*: Mweembe Chiabi, Jaimie Cogman, Bradley Stewart and Frazer Thomas.
*Ethan Vaughan and Jack Masrani will return after recovering from injury for pre-season assessment.