The two most "famous" recent encounters would be the 3 - 1 Luton victory in 2000 and the 2 - 1 Luton FA Cup win in 1994.
The day after Lennie Lawrence's Hatters beat Cardiff in January 2000 Frank Burrows left the club for the last time. His second spell as manager came to an end.
The 1994 FA Cup match was a 5th round tie after City had beaten Man City in round 4. The 1994 Luton side contained John Hartson.
So as well as exorcising the demons of Home Park City have a historial reason to beat Luton Town.
Dave Jones faces a defender dilemna as he has three centre backs to choose from. For the first time in ages all three can play with no suspensions affecting the matter.
The choice at the back looks like the only one Jones will have to make. There are no reports of any other problems so City are likely to start with
Alexander, McNaughton, two from Purse, Loovens and Johnson, Gilbert, Ledley, McPhail, Scimeca, Parry, Thompson, Chopra.
Luton will include Richard Langley in their team but no Russell Perrett. It will be of no surprise to the City fans that remember Perrett that he is injured.
Kick off is at 3:00pm on Saturday.